PhD Thesis Defense - Víctor Castrejón Comas

This PhD thesis focuses on the development of "smart" bandages designed to heal and monitor chronic wounds, such as those caused by diabetes. Since these wounds are difficult to treat and easily infected, this research explores advanced materials that can both repair skin and detect bacteria in real-time. The study centers on a base made of hyaluronic acid (HA)—a natural substance already found in our skin—transformed into a "click" hydrogel. This jelly-like material keeps the wound moist and helps the body naturally clear away dead tissue. To make the bandage "smart," a conductive plastic called PEDOT-MeOH is woven into the gel. This addition allows the bandage to conduct electricity without losing its softness or safety for the patient. By using computer simulations and laboratory testing, the research identifies the exact amount of conductive material needed to turn the bandage into a working sensor. The final device can "feel" NADH, a chemical signal produced by bacteria. If an infection starts, the bandage detects it immediately, even in complex environments. Ultimately, this work provides a powerful new tool that combines skin healing with early warning technology for safer, faster recovery.